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Migraines, Migraines…

Migraines, Migraines…

Posted by Steven Klayman on Sep 2nd 2019

Migraines affect an estimated 38 million Americans. They can strike both young and old, but a majority of sufferers are women, and/or between the ages of 35 and 55.

Worldwide, as many as 1 billion people are affected, making migraine the third most prevalent illness in the world. Yet, despite its prevalence, researchers still struggle to understand exactly how and why migraines occur. Adding to the complexity, there are several different types of migraines.

Migraine attacks are typically recurring, of moderate to severe intensity, many times occurring only on one side of your head. Along with throbbing, piercing or "burning" pain, other common symptoms include nausea, visual disturbances, dizziness, numbness in your extremities or face, and extreme sensitivity to light, sound, smell and touch.

An attack may last from a couple of hours to as long as three days, often requiring bed rest in complete darkness and silence. Generally speaking, migraine is thought to be a disorder of your central nervous system, most likely originating in your brain stem. While most brain regions do not register or transmit pain signals, the trigeminal nerve network does.

Pain is relayed through the trigeminal network to an area in your brain stem called the trigeminal nucleus. From there, it is conveyed to the sensory cortex in your brain that is involved in awareness of pain and other senses. However, what initially activates your trigeminal nerve to set off your migraine is still under debate.

One hypothesis is that a wave of neurotransmitters racing across your cortex can directly stimulate your trigeminal nerve, setting off a chain reaction that ends in the transmitting of pain signals.

In all likelihood, there are several mechanisms at play. We know, for example, that migraine is more common in women than men, and this has been linked to hormones.

    A migraine is more than just a bad headache. In a recent Greatist article, migraine sufferers were asked to describe their pain. Here are some of their answers:
  • "My head feels like it's in a vise." Triggers often include stress, weather changes, physical exertion, lack of sleep and/or eating the wrong foods. Artificial sweeteners such as aspartame are also known to commonly trigger migraine. Doctors suggest keeping a food diary to track the emergence of symptoms to pin down certain food triggers. You could do the same for weather and stress if you believe such factors may play a role.
  • It's "like when a light fixture starts to go out." This patient is describing the effects of ocular migraine, the onset of which often starts with flickering or flashing light phenomena, or zigzagging lines in the peripheral vision, which can eventually take over the entire field of vision. These visual disturbances are referred to as an "aura." Other common auras include blind spots, blurry, wavy or kaleidoscope vision. Auras can also involve other senses. For example, you may experience paresthesia (tingling or numbness), aphasia (trouble speaking), auditory hallucinations or smelling something that isn't there. Approximately one-quarter of all migraines are accompanied by aura, which is thought to be caused by a chemical or electrical wave in the brain region that processes sensory signals.
  • "It's like I've been staring at the sun." Oftentimes, the entire head, from the neck up, can feel overworked, "battered and bruised," or like your brain has been pounded with a hammer. Post-symptoms can also include a stiff neck for up to a day after the headache ends.
  • "Like I'm on a ship during a storm." Nausea and a feeling of being in motion are common.

One long-held theory was that a migraine is caused by vascular changes in your brain, from initial blood vessel constriction and a drop in blood flow, followed by dilation and stretching of blood vessels, which activates pain-signaling neurons.

Newer studies have negated this theory, however, as researchers determined migraines are not actually preceded by constriction and decrease in blood flow, but rather by a blood flow increase of nearly 300 percent.

Despite that, circulation appears normal, or even slightly reduced, once the attack is in full swing. The question remains: Why? One small observational study found that migraineurs tend to have a different blood vessel structure in their brains compared to those who do not get migraines.

Using magnetic resonance angiography, the researchers examined the structure of blood vessels and the changes in cerebral blood flow, focusing on a system of arteries that deliver blood to the brain called "circle of Willis."

They found that an incomplete circle of Willis was significantly more common in those who get migraines, with or without aura, compared to the control group (73 percent and 67 percent versus 51 percent, respectively).

As a result, compared to those with a complete circle of Willis, those with an incomplete circle had greater asymmetry in hemispheric cerebral blood flow. According to one of the authors of the study, Dr. John Detre, a professor of neurology and radiology: "Abnormalities in both the circle of Willis and blood flow were most prominent in the back of the brain, where the visual cortex is located. This may help explain why the most common migraine auras consist of visual symptoms such as seeing distortions, spots or wavy lines."

Interestingly, recent research suggests some migraines — primarily migraines without aura — may even be caused by a tear in your neck artery (arterial dissection), which raises your risk of stroke. Compared to people who had migraine with aura, those without aura were 1.7 times more likely to have an arterial tear. Arterial dissection and stroke were also more likely in men and those under the age of 39. Overall, your probability of having this problem is very low, but it may be worth getting it checked out.

Nutritional deficiencies can contribute to or cause a number of different health problems, including migraines. As for drug-free solutions for migraine and headache relief, including nutritional supplements, nutrients of particular importance here are vitamin D magnesium, Coenzyme Q10 (CoQ10) and riboflavin (vitamin B2), and deficiencies in one or more of these is quite common.

In a migraine study involving more than 7,400 children, teens and young adults, 16 to 51 percent of participants had below average levels of vitamins depending on the vitamin tested. Those suffering from chronic migraines were overall more likely to have CoQ10 and riboflavin deficiency compared to those with episodic migraines. Unfortunately, many of the patients in this study were prescribed preventive therapy and too few were given supplements alone for the researchers to determine if supplementation was enough to actually prevent migraines. However, other research suggests they can.

For example, research using vitamin D supplementation demonstrated a reduction in C-reactive protein (CRP) and a statistically significant reduction in headache frequency. Another more recent study by Finnish researchers found that men with the lowest vitamin D levels were twice more likely to suffer frequent headaches than those with the highest levels.

Overall, the lower the men's blood level of vitamin D, the more frequent their headaches. Those with a vitamin D blood level of 15.3 nanograms per milliliter (ng/mL) or lower typically had one or more headaches per week, while those with a level of 11.6 ng/mL or lower reported up to seven headaches per week. Ideally, your vitamin D level should be in the 40 to 60 ng/mL range, so both of these groups were severely deficient.

As reported by Deming Headlight: "The researchers theorized that vitamin D has anti-inflammatory properties that prevent swelling in the sensory neurons and the microglial cells in the brain, and is essential for proper brain function. In the study information, they also note that previous studies show vitamin D prevents musculoskeletal pain, a major cause of tension headaches."

According to research presented at the 50th Annual Meeting of the American Headache Society in 2010, nearly 42 percent of patients with chronic migraine were deficient in vitamin D. The study also showed that the longer you suffered from chronic migraines, the more likely you are to be vitamin D deficient.

Magnesium — which can affect both serotonin receptor function and the production and use of neurotransmitters — has also been shown to play an important role in the prevention and treatment of migraines, and migraine sufferers are more likely to suffer from magnesium deficiency than non-migraineurs.

Researchers theorize that migraine sufferers may develop magnesium deficiency from a variety of reasons, including poor absorption, renal wasting, and increased excretion due to stress or low nutritional intake. Since magnesium administration is both easy and safe, researchers have noted that empiric treatment with a magnesium supplement is justified for all migraine sufferers.

As a prophylactic, be prepared to boost your magnesium intake for at least three months to experience results, ideally in combination with CoQ10.

In many cases, receiving a high dose of magnesium can also abort an attack in progress. The most effective way to administer magnesium for migraine would be to get an intravenous (IV) infusion. I used to regularly administer magnesium IVs for those with acute migraines and it seemed to work for most patients to abort the headache.

Barring that option, magnesium threonate may be your best option for an oral supplement. It has superior absorbability compared to other forms of magnesium since its ability to cross the blood-brain barrier makes it more likely to have a beneficial effect on your brain.

Besides CoQ10, magnesium and vitamin D, other vitamin deficiencies linked to migraines include riboflavin (B2), B6, B12 and folic acid. One 2009 study evaluated the effect of 2 mg of folic acid, 25 mg vitamin B6 and 400 micrograms (mcg) of vitamin B12 in 52 patients diagnosed with migraine with aura.

Compared to the placebo group, those receiving these supplements experienced a 50 percent reduction in migraine disability over a six-month period. Previous studies have also reported that high doses of riboflavin can help prevent migraine attacks. For example, in one study patients who received 400 mg of riboflavin per day experienced a 50 percent reduction in migraine frequency after three months. Although supplements are convenient, it's important you get as many nutrients from your diet as possible, as your body can metabolize and absorb vitamins and minerals from your diet more effectively and efficiently than from most supplements.

In addition to adding foods rich in magnesium, riboflavin and CoQ10 to your daily diet, look for organic, grass-fed products to reduce your exposure to toxins and additional stressors. As for vitamin D, sensible sun exposure is your best bet. If you opt for a vitamin D3 supplement, be sure to increase your vitamin K2 and magnesium as well.

  • Foods Rich in Magnesium ...dark leafy greens, wild Alaskan salmon, nuts and seeds, bananas, and yogurt made from organic and/or grass fed milk with no added sugars
  • Foods Rich in Riboflavin ...spinach, beet greens, tempeh, crimini mushrooms, pastured eggs, almonds, and asparagus
  • Foods Rich in CoQ10...herring, grass-fed beef, organic pastured chicken, sesame seeds, broccoli, and cauliflower